Thus, to enhance the therapeutic effects of anti-tumor antibodies by removing immune suppressive regulatory signals, we first tested the combination of anti-tumor antibodies [TA99; anti- tyrosinase-related protein-1 (TYRP1) monoclonal antibodies] with antibody-mediated depletion of Treg cells in the B16 mouse model of melanoma. This evidence concerns the gene TYRP1 and neoplasm.