Thus, eliminating regulatory events (via antibody-mediated Treg depletion; Figure 1) or inducing activation of immune effectors (using anti-4-1BB agonistic mAb; Figure 2), enhanced the therapeutic effects of the TA99 anti-tumor monoclonal antibody (anti-TYRP1) in the B16 mouse model of melanoma. This evidence concerns the gene TYRP1 and melanoma.