ERBB2 and cancer: Targeting tumor antigens with specific antibodies, such as anti-CD20 (rituximab), anti-HER2 (trastuzumab), anti-EGFR (cetuximab), is well-established and has been relatively successful in a number of cancers, via interference with cellular signaling, complement-mediated lysis, antibody-dependent cell-mediated cytotoxicity (ADCC), and/or antibody-dependent cell phagocytosis (ADDP) [12–14, 16, 17].