Previous studies showed that the combination of TA99 with immunostimulatory molecules, such as toll-like receptor ligands and IL-2 has therapeutic effect dependent on a coordinated effect of the innate and adaptive anti-tumor immune response involving CD8+ T cells, NK and macrophages, and the expression of activating FcγR, which increases the success rates of tumor-targeting TA99 in eliminating tumor cells [24, 26, 27]. This evidence concerns the gene CD8A and neoplasm.