IgE overproduction activates IgE-mediated expression of Th1 and Th2 cytokines, and AD typical immune responses are associated with inflammatory infiltrates composed of lymphocytes, mast cells, dendritic cells, and macrophages, which secrete cytokines such as IL-4, IL-13, and IL-31 [39, 40]. This evidence concerns the gene IL31 and Alzheimer disease.