Interestingly, p-Akt and p-mTOR, two critical proteins involved in cell proliferation, were significantly downregulated in the MPTP group with no PSP treatment but were restored after PSP administration, especially at 30 mg/kg improving expression by 2.2-fold and 2.0-fold, respectively. Here, AKT1 is linked to supranuclear palsy, progressive, 1.