TNF and cancer: The key targets of Shiyifang Vinum were mainly concentrated in the cancer pathway, Hepatitis B and TNF signalling pathways, the HTLV-1 infection and toll-like receptor signalling pathways, the T-cell receptor signalling pathway, and the osteoclast differentiation and nod-like receptor signalling pathways, suggesting that they play an important role in the anti-inflammatory and analgesic effects of Shiyifang Vinum (Figures 2(a)–2(d)).