SMAD7 and renal fibrosis: As illustrated in Figure 2, the overlapped genes between renal fibrosis and skin fibrosis included CCL2, SIRT1, KLF5, PPARG, AKT1, SHH, NOTCH, SMAD7, TGFB1, CTNNB1, MMP2, CTGF, FN1, ITGB1, PLAUR, MMP14, NOX4, and COL1A1.