As illustrated in Figure 2, the overlapped genes between renal fibrosis and skin fibrosis included CCL2, SIRT1, KLF5, PPARG, AKT1, SHH, NOTCH, SMAD7, TGFB1, CTNNB1, MMP2, CTGF, FN1, ITGB1, PLAUR, MMP14, NOX4, and COL1A1. The gene discussed is CCN2; the disease is renal fibrosis.