H19 and Li-Fraumeni syndrome: In our previous studies, using a LFS patient-derived iPSC model, we demonstrated the tumor suppressor role of lncRNA H19 and the oncogenic role of SFRP2 during the formation of osteosarcoma in LFS patients (Lee et al., 2015; Lin et al., 2017b; Kim et al., 2018; Zhou et al., 2018).