Moreover, genes whose abnormal splicing was negatively correlated to SNORA7A expression were downstream targets of transcription factors such as the tumor angiogenesis regulator HIF1A (Koukourakis et al., 2002), the Hippo pathway transcription factor TEAD4 (Lin et al., 2017a; Shi et al., 2017) and the tumorigenic transcription factor NF-KB1 (Concetti and Wilson, 2018) (Figure 2G). This evidence concerns the gene NFKB1 and neoplasm.