ITGB3 and breast cancer: Among the genes carrying the seven RFS-related AS events, CGRRF1 suppresses the growth of BC cells including TNBC cells (Lee et al., 2019), FLAD1 upregulates the HIF pathway which is associated with poor prognosis of TNBC (Chen et al., 2014; Yang et al., 2017), ITGB3 is important for tumor cell migration and TNBC survival (Sesé et al., 2017), and PCYT2 activity has been shown to be increased in BC cells, enabling them to adapt to metabolic stress (Zhu and Bakovic, 2012; Mota et al., 2015).