U2SURP and breast cancer: This hypothesis is consistent with the involvement of POLR2E and U2SURP in BC discovered in previous studies (Brough et al., 2018; An et al., 2020), in agreement with the survival analysis results of the combined factors (Figures 8D,E) that their high values were significantly correlated with the high risk of TNBC survival, and also accordant with the Cox analysis results that the low PSI values of FLAD1_7874_RI were related to the high risk of TNBC survival (Figures 3A,C).