POLR2E and neoplasm: It indicated that SFs might abnormally regulate AS events, leading to high invasiveness, fast tumor growth, and low survival of TNBC (Park et al., 2019), such as the regulation of PCYT2_44231_AA by SRPK3 and the co-effects of POLR2E, U2SURP, and DOX39B on FLAD1_7874_RI to influence TNBC survival as concluded in this work.