Through the analysis of the correlation between these five genes and the pathological staging of colorectal adenocarcinoma based on GEPIA, we found that CCNA2, MAD2L1, DLGAP5, and RRM2 are all significantly related to the pathological stage of COAD and READ (P < 0.05), while AURKA is associated with the colorectal gland, with no significant correlation between cancer pathological staging (P > 0.05) (Figure 8A). The gene discussed is RRM2; the disease is colorectal adenocarcinoma.