In summary, it can be seen that CCNA2, MAD2L1, DLGAP5, RRM2, and AURKA are significantly related to the overall survival prognosis, disease-free survival, pathological stage, and lymph node metastasis stage of CRC, which are also important indicators for the evaluation of the prognosis of CRC and the evaluation of further treatment. This evidence concerns the gene DLGAP5 and colorectal carcinoma.