The correlation analysis of the expression of these five genes in colorectal adenocarcinoma showed that CCNA2 was highly correlated with MAD2L1 (P < 0.001, R = 0.88), and it was also correlated with DLGAP5 (P < 0.001, R = 0.78), AURKA (P < 0.001, R = 0.53), and RRM2 (P < 0.001, R = 0.68). This evidence concerns the gene RRM2 and colorectal adenocarcinoma.