Although no direct evidence has shown that the methylation alteration of MAP3K8 is functionally correlated with interleukins, such as IL-17, in the inflammation of airway smooth muscles, a recent publication on colorectal cancer has indicated that the methylation of MAP3K8 controls focal inflammatory responses via the regulation of related interleukins (Hartley, 2020). The gene discussed is IL17A; the disease is colorectal cancer.