In particular, the crosstalk and signaling cascades among I3K-AKT-mTOR, MAPK, AR, and Wnt improve the mechanistic insights into PCa tumorigenesis and accelerate the understanding in androgen-deprivation therapeutics for precision medicine and personalized healthcare of PCa patients (Shorning et al., 2020). Here, AKT1 is linked to posterior cortical atrophy.