TP53 and Familial prostate cancer: As illustrated in Figure 4B and Supplementary Table 2, most of the significantly enriched terms were closely involved in PCa development, such as Wnt signaling, prostate cancer, microRNAs in cancer, p53 signaling, PI3K-AKT signaling, and MAPK signaling etc. For example, Wnt signaling is implicated in PCa-related osteoblast differentiation as a key driver.