PCSK9 and familial hyperaldosteronism: It is well known now that homozygous or compound heterozygous FH patients with LDLR mutations or double-heterozygotes carrying LDLR and p.(R3500Q) APOB mutations have more severe phenotypes when compared to the heterozygote FH cases carrying only one mutation in any of the mentioned genes or for missense mutations in the PCSK9 gene.