The Consensus Panel on Familial Hypercholesterolemia of the European Atherosclerosis Society has previously stated that the general levels of LDL-C in double-heterozygous carriers of mutations in APOB, PCSK9, or LDLR to be less severely elevated as compared to homozygous carriers of variations in the same genes (Cuchel et al., 2014). The gene discussed is APOB; the disease is familial hypercholesterolemia.