More than 1,700 variants have been detected in the gene so far.1 Distinct mutations in other genes associated with LDL metabolism have also been shown to cause FH, including APOB (apolipoprotein B) (MIM #107730), PCSK9 (proprotein convertase substilin/kexin type 9) (MIM # 607786), and LDLRAP1 (low-density lipoprotein receptor associate protein 1) (MIM#605747) (Soutar and Naoumova, 2007; Singh and Bittner, 2015). This evidence concerns the gene PCSK9 and familial hyperaldosteronism.