These include autosomal-recessive (AR) deficiencies (IRF7 and IFNAR1) and autosomal-dominant (AD) deficiencies (TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, and IFNAR2) in 4 and 19 patients, respectively. The gene discussed is IFNAR1; the disease is Alzheimer disease.