mentioned above (153) was aimed inter alia at evaluation of association between PDCD1 polymorphisms and the risk of gastrointestinal cancer (a cancer group that affects the digestive system which contains inter alia esophageal cancer, esophagogastric junction adenocarcinoma, gastric cancer, hepatocellular carcinoma and colorectal cancer, which are separately described below). This evidence concerns the gene PDCD1 and esophageal cancer.