LAG-3 interacts with high affinity with its ligand—major histocompatibility complex class II (MHC II), Galectin 3 (soluble lectin expressed in a wide variety of cell types including tumor cells) and cell surface resident liver sinusoidal endothelial lectin (LSECtin, is expressed in the liver and on tumor cells) (223). The gene discussed is LGALS3; the disease is neoplasm.