The most recent meta-analysis published in 2020 (94) which relates to digestive system malignancies (among them gastric cancers) summarizes the results from available studies concerning the following CTLA-4 SNPs: CTLA-4c.-1772T>C, CTLA-4c.-1661A>G, CTLA-4c.-319C>T, CTLA-4c.49A>G, CTLA-4CT60G>A and gastric cancer (GC) risk (38, 95–100). The gene discussed is CTLA4; the disease is gastric cancer.