For instance, Foxp3 polymorphisms in promoter, exon, intron or Poly A region of Foxp3 gene locus have been detected in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D) and even in IPEX itself (150). The gene discussed is FOXP3; the disease is type 1 diabetes mellitus.