Conversely, the transferring-conjugated anionic lipopolyplex nanoparticle synthetic miR-29b mimics Tf-NP-miR-29b was shown to downregulate DNMTs, cyclin-dependent kinase (CDK) 6, SP1, KIT, and FLT3, to suppress AML growth, to impair colony formation, and to reduce cell viability in vitro in AML patient samples (87). This evidence concerns the gene SP1 and acute myeloid leukemia.