In vitro experiments on AML cells pointed out that miR-223 inhibits cell proliferation and stimulates cell apoptosis and also the fact that miR-223 target, F-box and WD repeat domain containing 7 (FBXW7), binds proteins such as c-myc, Jun, cyclin-E, and Notch leading to their proteasomal degradations (48). Here, MYC is linked to acute myeloid leukemia.