mir-34 exerts its growth inhibition on cancer cells by repressing HDAC1 (89), targeting factors required for G1/S transition (c-MYC, CDK6), anti-apoptotic proteins (Bcl2, sirtuin protein-SIRT1), proteins involved in invasion (c-MET) (90), and induction of sequential down modulating of Erk/Akt activity (91). Here, MYC is linked to cancer.