Our finding that mice with genetic deficiency in the PD-1/PD-L1 pathway are as susceptible to Py malaria infection as their WT counterparts highlights some unexpected discrepancies with prior work showing that therapeutic mAb blockade of PD-L1 in WT mice promotes enhanced control and clearance of blood parasitemia (8, 13). The gene discussed is PDCD1; the disease is parasitic infectious disease.