Likewise, a recent study using a newly generated 6hTau transgenic line (expressing an equal ratio of 3R and 4R human tau isoforms in null-background mice) states that distinct tauopathy strains recruit the corresponding tau isoforms present in AD, PSP, CBD, and PiD into tau aggregates in 6hTau mice (34). Here, MTA2 is linked to Alzheimer disease.