AKT1 and colon carcinoma: Rybchyn et al. (2011) reported that activation of the CaSR in human osteoblasts resulted in the AKT-dependent translocation of β-catenin to the nucleus. Wu et al. (2018) proved that activation of the CaSR attenuated the IL-1β-induced translocation of β-catenin. Bhagavathula et al. (2007) demonstrated that regulation of β-catenin in colon carcinoma is dependent on CaSR expression and function.