While the majority of studies address the effect of obesity associated with RAS hyperactivity through the ACE/Ang II/AT1 signaling pathway (Mathai et al., 2011), the ACE/Ang II/AT2 or ACE2/Ang 1-7/Mas/AT2 signaling pathways may be the key to elucidate the molecular mechanisms involved in protecting vascular homeostasis, especially during the development of pathological conditions such as obesity (Nguyen Dinh Cat and Touyz, 2011). The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.