KCNH2 and familial long QT syndrome: Several studies in animals and humans demonstrate the antiarrhythmic benefits of a lengthened PRRP (Koller et al., 1995; Franz, 2003; Fedorov et al., 2008) suggesting that the effect of hERG activators to prolong the PRRP in zebrafish hearts protects against TdP induction and demonstrates antiarrhythmic potential for the treatment of LQTS.