We hypothesized that in groups with high risk to develop severe COVID-19 (adults > children and men > women), (i) renin levels would increase with age and reach higher levels in adult men compared to adult women, that (ii) renin and sACE2 levels would be positively correlated, and that (iii) renin and sACE2 would be positively correlated with BMI. This evidence concerns the gene REN and COVID-19.