The SARS-CoV-1 and SARS-CoV-2 viruses enter lung cells by binding to mACE2 (Hoffmann et al., 2020), which upon SARS-CoV-1 infection has been shown to lead to ADAM-17 induced shedding of mACE2, and increased cellular release of tumor necrosis factor (Haga et al., 2008). Here, ADAM17 is linked to severe acute respiratory syndrome.