AGT and hypertensive disorder: Increased ROS in VSMCs is a common feature of different models of hypertension such as AngII-infused model (Rajagopalan et al., 1996;Zhou et al., 2020), spontaneously hypertensive rats (SHR) (Graton et al., 2019), renovascular hypertension (2K-1C) (Castro et al., 2012;Oliveira-Paula et al., 2016), and Doca-Salt rats (Amaral et al., 2015).