PIEZO1 and Tangier disease: It is important to distinguish Piezo1- and Gardos-HX because of several distinct clinical issues: non-spherocytic chronic hemolysis and risk of iron overload are common to both disorders, however, post-splenectomy thrombotic events and perinatal edemas without anemia are observed in Piezo1-HX, whereas anemia –including pre/neonatal anemia – are more severe in Gardos-HX (Fermo et al., 2017; Andolfo et al., 2018; Picard et al., 2019).