Several studies have shown that Nrf2 deficiency increases the sensitivity of dopaminergic neurons to MPTP and 6-OHDA neurotoxicity, and that Nrf2-dependent antioxidants are associated with high transcriptional activity and confer protective effects in various models of PD (Chen et al., 2009; Li et al., 2018). The gene discussed is NFE2L2; the disease is Parkinson disease.