PARP1 and cancer: Given that DNA damage can be induced selectively in cancer cells by exogenous oxidative stress (Trachootham et al., 2006; Gorrini et al., 2013; Harris et al., 2015; AbdulSalam et al., 2016), it appears that combining pro-oxidative agents with PARP inhibition could be a promising approach to generate synergistic cancer lethality.