CRP and rheumatoid arthritis: TGT can significantly decrease CRP and ESR in RA patients, which is similar to MTX, MDESR = –2.66, 95%CI [–8.17, 2.86], p = 0.35; MDCRP = –2.38, 95%CI [–9.01, 4.24], p = 0.48 (Li et al., 2019).