The analysis of Oil Red O stained area (Figure 7B) showed that acacetin treatment significantly decreased the aorta lesion area from 11.0 ± 1.12% (n = 11, p = 0.0014 vs. control) in non-treated STZ-diabetic ApoE−/− mice to 7.0 ± 0.6% (p = 0.0071 vs. STZ-diabetes). The gene discussed is APOE; the disease is diabetes mellitus.