FSHR and Infertility: Among the FSHR allosteric modulators evaluated to date (Palmer et al., 2005; Yanofsky et al., 2006; Arey et al., 2008; Van Stratten and Timmers, 2009; van Koppen et al., 2013), none had combined sufficient potency as FSHR agonists, oral bioavailability or adequate safety profiles (Gerrits et al., 2016) suitable for human infertility treatments (reviewed) (Nataraja et al., 2021).