TLR9 and cancer: Also the SNP rs187084 (T-1486C) of the TLR9 promoter previously being associated with rheumatic disease (Hegazy et al., 2019), cancers and pulmonary tuberculosis (Bharthi et al., 2014) has been suggested to provide relevant risk estimates for the development of sepsis and multiple organ dysfunction in critically ill patients (Chen et al., 2011).