In this study, in addition to paclitaxel-resistant ovarian cancer cell lines, SKOV3 and CaOV3, we also found that CPEB4 was upregulated at transcript and protein levels in recurrent ovarian tumors after treatment of paclitaxel-based chemotherapy, suggesting a molecular mechanism that transcriptionally regulates its expression induction is announced in ovarian cancer in response to paclitaxel. The gene discussed is CPEB4; the disease is ovarian cancer.