Moreover, CPEB4, one member of CPEBs, has been shown to play a key role in the progression of pancreatic ductal adenocarcinoma, glioblastoma, glioma and gastric cancer (Ortiz-Zapater et al., 2011; Zhijun et al., 2017; Cao et al., 2018). This evidence concerns the gene CPEB4 and pancreatic ductal adenocarcinoma.