PPARG and Crohn disease: The same is true for PPARγ, as Crohn’s disease-like ileitis is prevented in disease-susceptible SAMP/Fc mice crossbred with disease-resistant mice due to inheritance of functional PPARγ alleles, and certain polymorphisms in the PPARγ gene have been described as prevalent in Crohn’s disease patients (Sugawara et al., 2005).