AnxA1 can be cleaved at different cells and tissues, such as in neutrophils, adipose tissue and melanomas; non-functional 33-kDa peptides released promote inflammation facilitating cell transmigration to inflamed areas, inducing adipogenesis and causing skin tumors to become more aggressive (Williams et al., 2010; Boudhraa et al., 2014; Pietrani et al., 2018). Here, ANXA1 is linked to melanoma.