Data here obtained corroborated other studies which already evidenced the beneficial actions of pioglitazone in murine models of colitis (Saubermann et al., 2002; Takagi et al., 2002; Shah et al., 2007; Huang et al., 2020) and evidenced the lack of pioglitazone effects on AnxA1−/− mice demonstrating the pivotal role of AnxA1 for pioglitazone anti-inflammatory actions. Here, ANXA1 is linked to colitis.