Moreover, the inhibition of Jmjd3 and UTX reduced albuminuria, podocyte foot process effacement, and Jag1 upregulation in diabetic mice, indicating that shifts in podocyte H3K27me3 levels may influence the development and outcomes of glomerular injury in DN (Majumder et al., 2018). The gene discussed is JAG1; the disease is liver dysplastic nodule.