BCL2 and diabetes mellitus: In this context, another ARB, valsartan, also inhibited the activation of Notch, B-Cell CLL/Lymphoma 2 (Bcl-2) and p53 apoptotic pathways, and reduced apoptosis and podocyte detachment and loss in the glomeruli of mice with streptozotocin-induced diabetes (Gao et al., 2016).