To further examine the mechanism of IQGAP3 in the development of breast cancer radioresistance, we performed GSEA and found IQGAP3 expression positively correlates with DNA repair gene signatures (HALLMARK_DNA_REPAIR) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling-activated gene signatures (HALLMARK_PI3K_AKT_MTOR_SIGNALING) in published TCGA gene expression profiles. This evidence concerns the gene IQGAP3 and breast cancer.