For example, IQGAP3 knockdown inhibited proliferation and ERK activity in cultured epithelial cells (Nojima et al., 2008); IQGAP3 was also found to activate EGFR–ERK signaling and, thus, promote the metastasis of lung cancer cells (Yang et al., 2014). The gene discussed is IQGAP3; the disease is lung carcinoma.