IL-6, TNFα and B lymphocytes have been reported to play a crucial role in the inflammatory cascade taking place days before the manifestation of the most severe forms of SARS-CoV-2 infection (Zhou et al., 2020), as well as in the physiopathological processes leading to rheumatoid arthritis (Ceribelli et al., 2020). The gene discussed is TNF; the disease is rheumatoid arthritis.