INS and cancer: The top 10 significantly enriched pathways (p < 0.05) were ATP-binding cassette (ABC) transporters, pyrimidine metabolism, glucagon signaling pathway, nonalcoholic fatty liver disease (NAFLD), glycolysis/gluconeogenesis, purine metabolism, central carbon metabolism in cancer, insulin signaling pathway, galactose metabolism, and FoxO signaling pathway (Figure 5B).