NPPB and congestive heart failure: NT-proBNP will be detected centrally by Zhejiang Chinese Medical University using a standard kit and fixed operating procedures; 2) improvement in NYHA functional class (The Criteria Committee of the New York Heart Association, 1994); 3) improvement in the Minnesota Living with Heart Failure Questionnaire score (Rector and Cohn, 1992); 4) improvement in echocardiographic measurements of left ventricular end-diastolic diameter and LVEF; 5) the incidence rate of clinical endpoint events (rehospitalization for acute aggravation of CHF, cardiogenic death, and all-cause death).