IL1B and ischemic stroke: One recent study using an ischemic stroke model in rats by transient middle cerebral artery occlusion (MCAO) showed that the use of 100 mg/kg of KPF intragastrically administered for 7 days was able to inhibit microglia activation and expression of TNFα and interleukins such as IL-6, IL-1β, and IL-5.