Recent studies have found that eIF4F (Cerezo et al., 2018), BRD4 (Zhu et al., 2016) are respectively associated with the translational and transcriptional regulation of PD-L1, furthermore, their respective inhibitors silvestrol, JQ1 all show obvious tumor suppressive effects, which suggests that there is large development space to excavate. The gene discussed is CD274; the disease is neoplasm.