SNCA and Anxiety: In addition, the overexpression of α-synuclein in striatum, substantia nigra, olfactory bulb, hippocampus, amygdala, prefrontal cortex, locus coeruleus, and colon are involved in non-motor features such as anxiety, depression or cognitive decline (Jellinger, 2011; Shannon et al., 2012; Flores-Cuadrado et al., 2016; Schapira et al., 2017; Butkovich et al., 2018; Henrich et al., 2018; Stoyka et al., 2020).