It was consistent with the previous studies that acupuncture at a group of acupoints including BL23 as one of the major acupoints could relieve the symptoms of many disorders by improving the cerebral hemodynamics and cognitive deficits in the hippocampal CA1 region and rebalancing HPA-associated plasma hormones including E2, T, CORT, LH, and GnRH, or inhibiting the expression of orexin in the lateral hypothalamus (Wang et al., 2017, 2020; Zhang et al., 2017; Ji et al., 2019; Jing et al., 2020). Here, PLOD1 is linked to Cognitive impairment.