ZNF423 and Joubert syndrome: More recently, ZNF423/Zfp423, a gene implicated in rare cases of Joubert syndrome, was found to be required for the response to SHH (Hong and Hamilton, 2016), for DNA repair (Chaki et al., 2012; Casoni et al., 2017) and CGP cell cycle progression (Casoni et al., 2017).