Given the results of our previous studies that showed acupuncture at HTWP improved the consciousness level of coma patients with several CNS injuries, our present work elucidated that HTWP acupuncture may activate P2RX7-expressing dopaminergic neurons in the vPAG, increase DA production and release to enhance ARAS neural projection, and promote the awakening of TBI rats in comas. Here, P2RX7 is linked to Coma.