P2RX3 and type 2 diabetes mellitus: Thus, we analyzed the distribution of P2RX7, P2RX3, and TRPV1 in the vPAG of sham and TBI rats without or with HTWP acupuncture treatment using confocal microscopy (Figures 3A–C) to verify that HTWP acupuncture regulates the expression of these receptors in the vPAG to reduce coma duration.