The results show that the HTWP-acupuncture alleviation of the TBI-induced coma duration was offset by the i.c.v injection of P2RX7, P2RX3, and TRPV1 antagonists (Figures 6C–E), indicating that P2RX7, P2RX3, and TRPV1 signaling pathways mediate the awakening effect of acupuncture at HTWP. Here, P2RX7 is linked to Coma.