TSC1 and neoplasm: Another condition, tuberous sclerosis (TSC), involves mutation of either TSC1 and TSC2 genes that codes for proteins hamartin and tuberin, which act as tumor suppressors that regulate cell growth and the mTORC1 complex (Astrinidis and Henske, 2005; Inoki et al., 2005; Curatolo and Bombardieri, 2007).