Further, there is strong evidence that the genetic risk for AD that has been associated with polymorphisms in both Apoliprotein E (ApoE) and Clusterin (CLU) is at least partly attributable to effects of these proteins on Aβ deposition (Ray et al., 1998; Tanzi, 2012; Bettens et al., 2013; Karch et al., 2014; Tcw and Goate, 2017; Belloy et al., 2019). The gene discussed is CLU; the disease is Alzheimer disease.