Studies in neuroblastoma cells have shown an upregulation of GnT-III in response to Aβ treatment, and reduced Aβ load in GnT-III transfected cells, hypothesizing a protective effect of N-glycans, and upregulation of GnT-III as an adaptive response in AD brains (Akasaka-Manya et al., 2010). The gene discussed is MGAT3; the disease is Alzheimer disease.