Together with the evidence of altered sialylation in AD, such as decreased ST levels in these patients, desialylation of the microglial surface has been shown to be induced by activating stimuli such as LPS, Aβ and Tau, which can in turn enhance the complement receptor 3 (CR3) mediated phagocytosis of neurons (Allendorf et al., 2020). Here, MAPT is linked to Alzheimer disease.