CLU and Alzheimer disease: Decreased ST activity and altered glycosylation of transferrin, an iron transport mediator, together with clusterin (CLU), an important player in debris clearance and apoptosis, both being genetically linked to AD, have been observed in AD blood samples (Maguire et al., 1994; Van Rensburg et al., 2004; Liang et al., 2015), making them potential blood biomarker candidates.