The search for direct targets of miR-138 lead us to focus on Sirt1, known to play a role in modulating Aβ and importantly, behavior such memory and anxiety in mice (Gao et al., 2010; Libert et al., 2011; Hernandez-Rapp et al., 2016; Lu et al., 2019). The gene discussed is SIRT1; the disease is Anxiety.