SETDB1 has recently been reported to be required for formation of PC in mice by inhibiting p53-mediated apoptosis [48], and FAM63A/MINDY1 has been found to interact significantly with diabetes (duration ≥ 3 years) in a meta-analysis on PC risk conducted within the PanC4 and PanScan consortia [49]. This evidence concerns the gene SETDB1 and pachyonychia congenita.