The alternative allele (T) of this SNP is associated with a decreased expression of XBP1 in normal pancreas in GTEx (− 0.19, p value = 1.3 × 10−4) and with an increased risk of PC in our GWAS (OR = 1.28, p value = 8.71 × 10−3). This evidence concerns the gene XBP1 and pachyonychia congenita.