Quick degradation of PSMD11 protein has been found to be associated with acute apoptosis in cancer cells, and its knockdown by siRNA can promote acute apoptosis in pancreatic cancer cells [18], suggesting that PSMD11 may be a multi-functional protein, and may be a novel therapeutic target for cancer, whether it can be targeted to treat cancer deserve further investigation. The gene discussed is PSMD11; the disease is familial pancreatic carcinoma.