In our work, TEAD4 overexpression significantly increased the proliferation of KYSE-30 cells which was observed by CCK8, colony formation, and EDU staining, as well as the malignant behaviors of KYSE-30 cells including proliferation, migration, and invasion, indicating that TEAD4 could be closely associated with the progression of ESCC. Here, TEAD4 is linked to esophageal squamous cell carcinoma.