SPOCK1 can be modulated by CHD1L, and elevated SPOCK1 expression facilitates HCC tumorigenesis in mice by activating Akt signaling and represses HCC cell apoptosis via regulating the release of cytochrome c and activities of caspase-3 and caspase-9 [20]. The gene discussed is CASP3; the disease is hepatocellular carcinoma.